Phenylethanolamine N-methyltransferase kinetics: Bovine versus recombinanthuman enzyme

Authors
Grunewald, GL McLeish, MJ Criscione, KR
Citation
Gl. Grunewald et al., Phenylethanolamine N-methyltransferase kinetics: Bovine versus recombinanthuman enzyme, BIOORG MED, 11(12), 2001, pp. 1579-1582
Citations number
26
Categorie Soggetti
Chemistry & Analysis
Journal title
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
ISSN journal
0960894X → ACNP
Volume
11
Issue
12
Year of publication
2001
Pages
1579 - 1582
Database
ISI
SICI code
0960-894X(20010618)11:12<1579:PNKBVR>2.0.ZU;2-3
Abstract
Epinephrine (Epi) acts as a neurotransmitter in the brain, but its function therein is not well understood. Phenylethanolamine N-methyltransferase (PN MT) catalyzes the final step in the biosynthesis of Epi and is thus a pharm acological target to investigate the function of Epi in the central nervous system. The kinetic differences between bovine adrenal PNMT and human brai n PNMT for a number of substrates and inhibitors are examined and the resul ts reported. (C) 2001 Elsevier Science Ltd. All rights reserved.