RAPID FLUOROUS STILLE COUPLING REACTIONS CONDUCTED UNDER MICROWAVE IRRADIATION

Authors
LARHED M HOSHINO M HADIDA S CURRAN DP HALLBERG A
Citation
M. Larhed et al., RAPID FLUOROUS STILLE COUPLING REACTIONS CONDUCTED UNDER MICROWAVE IRRADIATION, Journal of organic chemistry, 62(16), 1997, pp. 5583-5587
Citations number
84
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Journal of organic chemistry → ACNP
ISSN journal
00223263
Volume
62
Issue
16
Year of publication
1997
Pages
5583 - 5587
Database
ISI
SICI code
0022-3263(1997)62:16<5583:RFSCRC>2.0.ZU;2-D
Abstract
Palladium-catalyzed fluorous Stille cross-coupling reactions with orga nic halides or triflates require only 90-120 s for completion when con ducted under microwave irradiation. Comparable thermal reactions requi re about 1 day. Fourteen different coupling products were synthesized and isolated in good yields after three-phase extraction (FC-84, dichl oromethane, water) and chromatography. The examples extend the scope o f the fluorous Stille coupling with respect to both the tin and halide /triflate components. Applications in parallel synthesis are suggested .