Human urotensin II-induced contraction and arterial smooth muscle cell proliferation are mediated by RhoA and Rho-kinase

Authors
Sauzeau, V Le Mellionnec, E Bertoglio, J Scalbert, E Pacaud, P Loirand, G
Citation
V. Sauzeau et al., Human urotensin II-induced contraction and arterial smooth muscle cell proliferation are mediated by RhoA and Rho-kinase, CIRCUL RES, 88(11), 2001, pp. 1102-1104
Citations number
16
Categorie Soggetti
Cardiovascular & Hematology Research
Journal title
CIRCULATION RESEARCH
ISSN journal
00097330 → ACNP
Volume
88
Issue
11
Year of publication
2001
Pages
1102 - 1104
Database
ISI
SICI code
0009-7330(20010608)88:11<1102:HUICAA>2.0.ZU;2-9
Abstract
The aim of this work was to investigate the coupling of human urotensin II (hU-II) to RhoA activation and regulation of RhoA-dependent functions. The use of the Rho-kinase inhibitor Y-27632 and the development of a membrane-p ermeant RhoA inhibitor (TAT-C3) allowed us to demonstrate that hU-II induce d arterial smooth muscle contraction, actin stress fiber formation, and pro liferation through the activation of the small GTPase RhoA and its downstre am effector Rho-kinase.