Recalibration of the point-of-care test for CARDIAC T Quantitative with Elecsys Troponin T 3rd generation

The rapid troponin T assay CARDIAC T Quantitative was recalibrated using El ecsys Troponin T 3rd Generation as a new reference method. This paper prese nts the method comparisons at six centres using the new reference method. M ethod comparison between CARDIAC T Quantitative Versus Elecsys Troponin T 3 rd Generation were performed using 319 samples from patients with acute cor onary syndromes. The quality of the CARDIAC T Quantitative was controlled b y a daily single determination of CARDIAC Control Troponin T, and for the E lecsys Troponin T 3rd Generation, the Elecsys controls were included in eac h run. The results for the control materials for the CARDIAC T Quantitative were between 93% and 107% of the target Values. The CV ranged from 7% to 1 6%. From the regression analysis, according to Bablok and Passing (y = 1.07 x) and the Bland and Altman plot, the bias between CARDIAC T Quantitative a nd Elecsys Troponin T 3rd Generation is from +6% to +7%, The correlation co efficient is 0.93, and a 3 x 3 comparison of the clinical efficiency yielde d 92% clinical concordance between CARDIAC T Quantitative and Elecsys Tropo nin T 3rd Generation. In conclusion, CARDIAC T Quantitative was in good agr eement with the reference and calibration method Elecsys Troponin T 3rd Gen eration. (C) 2001 Published by Elsevier Science B.V.