The impact of chronic illness on subjective quality of life: A comparison between general population and hospital inpatients with somatic and psychiatric diseases

In a comparative study 1720 healthy persons from the general population and 242 hospital patients with the ICD-IO diagnosis Cancer, Heart Disease, Dia betes, Multiple Sclerosis, Arthritis, Diseases of the Respiration System an d Schizophrenia completed the WHOQOL-BREF. The results of comparative multi ple regression analysis show that the different diseases have a characteris tic impact on the four subscales of the WHOQOL-BREF. Somatic diseases were found to have a strong negative impact on physical health, psychological we ll-being, and overall quality of life but not on social relationships. Amon g the somatic diseases only arthritis and multiple sclerosis had a signific ant negative impact on the environmental domain of quality of life. Schizop hrenia was found to have a significant negative impact on physical health, psychological well-being, social relationships, environment, and on overall qualify of life. For the different somatic diseases the results of the stu dy indicate that a decrease in quality of life is not primarily a result of the severity of the disease in the sense of its mortality, but more a resu lt of the impairment in daily functioning resulting from the disease. The b roader impact of schizophrenia in contrast to that of the somatic diseases, seems to result from the negative social reactions and the economic depriv ation often associated with this type of mental illness. Copyright (C) 2001 John Wiley & Sons, Ltd.