Qualitative and quantitative analyses of resin-bound organic compounds

Authors
Irving, M Cournoyer, J Li, RS Santos, C Yan, B
Citation
M. Irving et al., Qualitative and quantitative analyses of resin-bound organic compounds, COMB CHEM H, 4(4), 2001, pp. 353-362
Citations number
15
Categorie Soggetti
Chemistry & Analysis
Journal title
COMBINATORIAL CHEMISTRY & HIGH THROUGHPUT SCREENING
ISSN journal
13862073 → ACNP
Volume
4
Issue
4
Year of publication
2001
Pages
353 - 362
Database
ISI
SICI code
1386-2073(200106)4:4<353:QAQAOR>2.0.ZU;2-D
Abstract
Methods for qualitative and quantitative analyses of resin-bound organic co mpounds are essential tools for chemistry development in solid-phase combin atorial and parallel syntheses. Here we discuss the use of gel-phase F-19 N MR, the fluoride ion-selective electrode method, and spectrophotometry for monitoring solid-phase reactions. Our results indicate that the application of these diverse methods for analyzing the outcome of solid-phase combinat orial synthesis are sensitive and conclusive.