The neuregulins are a complex family of factors that perform many functions
during neural development. Recent experiments have shown that neuregulins
promote neuronal migration and differentiation, and regulate the selective
expression of neurotransmitter receptors in neurons and at the neuromuscula
r junction. They also regulate glial commitment, proliferation, survival an
d differentiation. At interneuronal synapses, neuregulin ErbB receptors ass
ociate with PDZ- domain proteins at postsynaptic densities where they can m
odulate synaptic plasticity. How this combinatorial network comprising many
neuregulin ligands that signal through distinct combinations of dimeric Er
bB receptors - elicits its multitude of biological effects is beginning to
be resolved.