Coordinate regulation of metabotropic glutamate receptors

Authors
Alagarsamy, S Sorensen, SD Conn, PJ
Citation
S. Alagarsamy et al., Coordinate regulation of metabotropic glutamate receptors, CUR OP NEUR, 11(3), 2001, pp. 357-362
Citations number
60
Categorie Soggetti
Neurosciences & Behavoir
Journal title
CURRENT OPINION IN NEUROBIOLOGY
ISSN journal
09594388 → ACNP
Volume
11
Issue
3
Year of publication
2001
Pages
357 - 362
Database
ISI
SICI code
0959-4388(200106)11:3<357:CROMGR>2.0.ZU;2-V
Abstract
Recent studies aimed at identifying the mechanisms that regulate the signal ing of metabotropic glutamate receptors (mGluRs) have revealed that both pr otein kinase and protein phosphatase activity are important in directly mod ulating mGluR function. The inter-relationship between phosphorylation and dephosphorylation of mGluRs seems to be an important determinant in regulat ing mGluR function and the subsequent neuromodulatory events elicited by ac tivation of mGluRs.