Allosteric mechanisms in normal and pathological nicotinic acetylcholine receptors

Authors
Changeux, JP Edelstein, SJ
Citation
Jp. Changeux et Sj. Edelstein, Allosteric mechanisms in normal and pathological nicotinic acetylcholine receptors, CUR OP NEUR, 11(3), 2001, pp. 369-377
Citations number
110
Categorie Soggetti
Neurosciences & Behavoir
Journal title
CURRENT OPINION IN NEUROBIOLOGY
ISSN journal
09594388 → ACNP
Volume
11
Issue
3
Year of publication
2001
Pages
369 - 377
Database
ISI
SICI code
0959-4388(200106)11:3<369:AMINAP>2.0.ZU;2-L
Abstract
Recent chemical and advanced structural studies on site-directed and natura lly occurring pathological mutants of individual members of the multigene f amily of nicotinic acetylcholine receptors have yielded structure-function relationships supporting indirect 'allosteric' interactions between the ace tylcholine-binding sites and the ion channel in signal transduction.