Determination of protein function, evolution and interactions by structural genomics

Authors
Teichmann, SA Murzin, AG Chothia, C
Citation
Sa. Teichmann et al., Determination of protein function, evolution and interactions by structural genomics, CURR OP STR, 11(3), 2001, pp. 354-363
Citations number
83
Categorie Soggetti
Biochemistry & Biophysics
Journal title
CURRENT OPINION IN STRUCTURAL BIOLOGY
ISSN journal
0959440X → ACNP
Volume
11
Issue
3
Year of publication
2001
Pages
354 - 363
Database
ISI
SICI code
0959-440X(200106)11:3<354:DOPFEA>2.0.ZU;2-2
Abstract
The genome sequencing projects and knowledge of the entire protein repertoi res of many organisms have prompted new procedures and techniques for the l arge-scale determination of protein structure, function and interactions. R ecently, new work has been carried out on the determination of the function and evolutionary relationships of proteins by experimental structural geno mics, and the discovery of protein-protein interactions by computational st ructural genomics.