Isolated Pneumocystis carinii infection of adrenal glands causing Addison's disease in a non-immunocompromised adult

Citation
J. Agarwal et al., Isolated Pneumocystis carinii infection of adrenal glands causing Addison's disease in a non-immunocompromised adult, ENDOCR PATH, 12(1), 2001, pp. 87-91
Citations number
8
Categorie Soggetti
Endocrinology, Nutrition & Metabolism
Journal title
ENDOCRINE PATHOLOGY
ISSN journal
10463976 → ACNP
Volume
12
Issue
1
Year of publication
2001
Pages
87 - 91
Database
ISI
SICI code
1046-3976(200121)12:1<87:IPCIOA>2.0.ZU;2-F
Abstract
Pneumocystis carinii is primarily an opportunistic pathogen infecting patie nts with AIDS and other immunocompromised patients, and ordinarily does not affect immunocompetent persons. We report isolated P. carinii Infection of bilateral adrenal glands in a non-immunocompromised adult male, leading to fatal Addisonian crisis. Diagnosis of P. carinii was established on the ba sis of cytopathology and microbiological tests, using conventional staining techniques and direct immunofluorescence on ultrasound-guided fine needle aspirates and trucut needle biopsy specimen from adrenal glands. P. carinii pneumonia and other fungal infections of the adrenal glands were excluded by appropriate tests. Absence of HIV infection was established by negative ELISA for HIV I and II antibodies and Western blot analysis at the time of presentation and 45 d later. Normal blood total leukocyte and CD4 lymphocyt e counts and IgG and IgA levels confirmed the immunocompetent status of the patient. The patient improved with anti-Pneumocystis treatment and cortico steroid replacement, but succumbed to an episode of Addisonian crisis trigg ered by a diarrheal illness.