Determination of N-nitrosodimethylamine in artificial gastric juice by gaschromatography-mass spectrometry and by gas chromatography-thermal energy analysis
Jw. Dallinga et al., Determination of N-nitrosodimethylamine in artificial gastric juice by gaschromatography-mass spectrometry and by gas chromatography-thermal energy analysis, EUR J CAN P, 10(3), 2001, pp. 265-268
The thermal energy analyser (TEA) is considered to be the gold standard for
the determination of nitrosamines. However, since many laboratories cannot
justify the use of such a very specific detection system, alternative dete
ction methods are useful. While standard gas chromatography (GC) detectors
lack the selectivity of the TEA detector, mass spectrometry (MS) seems to b
e the method of choice to combine GC separation with mass selective detecti
on. Moreover, the detection limits of the GC-MS assay in general use are ab
out 4 times lower than those of the GC-TEA assay. A comparison of GC-MS and
GC-TEA data on N-nitrosodimethylamine determinations showed a strong corre
lation between the two assays (R-2 = 0.86), demonstrating the exchangeabili
ty of these methods. (C) 2001 Lippincott Williams & Wilkins.