Convergent synthesis and diversity of amino acid based dendrimers

The synthesis of amino acid based dendrimers 25 (fifth generation, 32 endgr oups), 30 (fourth generation, 81 endgroups), chiral dendrimer 23 (third gen eration, 8 endgroups) as well as core-modified dendrimers 34 and 38 by the convergent method is described. The amino acid building blocks are derived from hydroxybenzoic acid derivatives and amino alcohol derivatives, and acc ess to a considerable molecular diversity of these novel dendrimers can be achieved. The synthesis can be carried out on a relatively large scale, and this easy access of the dendrimers may lead to many potential applications .