In vitro evaluation of 2,4-dihydroxythiobenzanilides against various moulds

The antimycotic potency of 2,4-dihydroxythiobenzanilide derivatives was tes ted. The MIC assessments by an agar dilution method were used for the estim ation of potential activity in vitro against the four mould strains: Scopul ariopsis brevicalis, Aspergillus niger, Aspergillus fumigatus and Penicilli um sp. The strongest fungistatic activity was observed for 3 ' -fluoro-deri vative (MIC 7.82 mug/ml). It was stated that the inhibition action of these compounds depends mainly on lipophilicity of molecules. Parabolic relation ships between the antimycotic activity and lipophilicity were found. (C) 20 01 Elsevier Science B.V. All rights reserved.