Olanzapine in relapsing schizophrenia. Efficacy and serotonergic parameters

Citation
R. Mooren et al., Olanzapine in relapsing schizophrenia. Efficacy and serotonergic parameters, EUR J PSYCH, 15(2), 2001, pp. 91-100
Citations number
28
Categorie Soggetti
Psychiatry
Journal title
EUROPEAN JOURNAL OF PSYCHIATRY
ISSN journal
02136163 → ACNP
Volume
15
Issue
2
Year of publication
2001
Pages
91 - 100
Database
ISI
SICI code
0213-6163(200104/06)15:2<91:OIRSEA>2.0.ZU;2-Z
Abstract
In the present study, olanzapine was administered to 20 hospitalized schizo phrenic patients with an acute episode of relapsing disease, following an o pen baseline controlled design. In addition to assessment of efficacy and s afety, the effects of treatment on plasma levels of amino acids, 5-HT param eters and norharman were evaluated. Olanzapine induced antipsychotic effect s without inducing any EPS and was associated with significant weight gain in a majority of patients. In half of the nonresponders, a subjective impro vement of well being and general functioning was observed that could not be related to reduction of psychopathological features. Nonresponders appeare d to present with clinically more severe arousal-like symptoms as assessed with a subset of PANSS items. Non-response to treatment with olanzapine was found to be associated with lower 5-HT plasma concentrations at baseline a nd enhanced 5-HIAA plasma levels during the experimental period.