Normal IncA expression and fusogenicity of inclusions in Chlamydia trachomatis isolates with the incA I47T mutation

Authors
Pannekoek, Y van der Ende, A Eijk, PP van Marle, J de Witte, MA Ossewaarde, JM van den Brule, AJC Morre, SA Dankert, J
Citation
Y. Pannekoek et al., Normal IncA expression and fusogenicity of inclusions in Chlamydia trachomatis isolates with the incA I47T mutation, INFEC IMMUN, 69(7), 2001, pp. 4654-4656
Citations number
16
Categorie Soggetti
Immunology
Journal title
INFECTION AND IMMUNITY
ISSN journal
00199567 → ACNP
Volume
69
Issue
7
Year of publication
2001
Pages
4654 - 4656
Database
ISI
SICI code
0019-9567(200107)69:7<4654:NIEAFO>2.0.ZU;2-K
Abstract
To investigate the correlation between the incA I47T mutation in Chlamydia trachomatis and the nonfusogenic phenotype, the incA genes of 25 isolates w ere sequenced. Four major sequence types were identified. Seven isolates (2 8%) had the I47T mutation. Isolates representing the four sequence types ex pressed incA in the membrane of one large single inclusion. In conclusion, the incA I47T mutation is not associated with the nonfusogenic phenotype.