Hyphae and yeasts of Candida albicans differentially regulate interleukin-12 production by human blood monocytes: Inhibitory role of C-albicans germination

Authors
Liu, LM Kang, KF Takahara, M Cooper, KD Ghannoum, MA
Citation
Lm. Liu et al., Hyphae and yeasts of Candida albicans differentially regulate interleukin-12 production by human blood monocytes: Inhibitory role of C-albicans germination, INFEC IMMUN, 69(7), 2001, pp. 4695-4697
Citations number
13
Categorie Soggetti
Immunology
Journal title
INFECTION AND IMMUNITY
ISSN journal
00199567 → ACNP
Volume
69
Issue
7
Year of publication
2001
Pages
4695 - 4697
Database
ISI
SICI code
0019-9567(200107)69:7<4695:HAYOCA>2.0.ZU;2-K
Abstract
The role of Candida albicans yeast-to-hypha transition in interleukin-12 (I L-12) production by monocytes was investigated. Germinating C. albicans not only failed to induce IL-12 p70 but also suppressed IL-12 production induc ed by heat-killed C. albicans, Comparison of the abilities of germinating C , albicans and agerminating mutants to inhibit IL-12 production showed that germination of C. albicans plays a critical role in the inhibition of IL-1 2 production.