Growth hormone does not affect albumin synthesis in the critically ill

Citation
H. Barle et al., Growth hormone does not affect albumin synthesis in the critically ill, INTEN CAR M, 27(5), 2001, pp. 836-843
Citations number
41
Categorie Soggetti
Aneshtesia & Intensive Care
Journal title
INTENSIVE CARE MEDICINE
ISSN journal
03424642 → ACNP
Volume
27
Issue
5
Year of publication
2001
Pages
836 - 843
Database
ISI
SICI code
0342-4642(200105)27:5<836:GHDNAA>2.0.ZU;2-N
Abstract
Objective: To study the effect of growth hormone (GH) on albumin synthesis in critically ill patients. Design: Prospective randomized controlled study. Setting: Two intensive care units, university hospital and county hospital, respectively. Patients: Twenty-two critically ill patients in the intensive care unit. Interventions: Albumin synthesis was measured twice in each patient. with a 5-day interval. The patients in the control group (n = 11) received standa rd intensive care unit (ICU) treatment between measurements, whereas those in the GH group (n = 11) also received 0.3 U/kg daily of human recombinant GH. Measurements and results: Albumin synthesis was measured by labeling with L -[H-2(5)]phenylalanine In the control group, the fractional synthesis rate (FSR) of albumin was 16.3 +/- 4.1%/day (mean and SD) in the first measureme nt and 15.7 +/- 4.2 %/day 5 days later (NS), whereas in the GH group the co rresponding values were 17.0 +/- 4.7 %/day and 16.7 +/- 5.5 %/day (NS). The calculated absolute synthesis rates of albumin, based on FSR and intravasc urar albumin mass, also showed no effect of GH. Conclusion: Albumin synthesis rates were consistently higher in the two gro ups of critically ill patients than previously reported values in healthy s ubjects. However, GH treatment for 5 days neither stimulated nor inhibited albumin synthesis rates in these critically ill patients.