Temporal bone histopathology in trisomy 22

Trisomy 22 has multiple physical anomalies, and aural malformations are com monly associated with trisomy 22. However, there has been only one report d escribing the temporal bone histopathology in trisomy 22. Our case is the s econd reported temporal bone histopathology of trisomy 22. Aural anomalies in this case were less serious than those earlier described, though showing Mondini dysplasia of the bony and membranous labyrinth. Deafness in patien ts with trisomy 22 may manifest sensorineural. conductive or mixed hearing losses, and/or vestibular dysfunction of varying degrees, according to the site and severity of aural anomalies. (C) 2001 Elsevier Science Ireland Ltd . All rights reserved.