FAST-ATOM-BOMBARDMENT MASS-SPECTROMETRIC STUDY OF SATE FOSCARNET PRODRUGS AND OF A SERIES OF FOSCARNET-AZT CONJUGATES

Authors
ROZENSKI J MEIER C AUBAGNAC JL ASTIER R HERDEWIJN P IMBACH JL GOSSELIN G
Citation
J. Rozenski et al., FAST-ATOM-BOMBARDMENT MASS-SPECTROMETRIC STUDY OF SATE FOSCARNET PRODRUGS AND OF A SERIES OF FOSCARNET-AZT CONJUGATES, Rapid communications in mass spectrometry, 11(11), 1997, pp. 1212-1218
Citations number
41
Categorie Soggetti
Spectroscopy,"Chemistry Analytical
Journal title
Rapid communications in mass spectrometry → ACNP
ISSN journal
09514198
Volume
11
Issue
11
Year of publication
1997
Pages
1212 - 1218
Database
ISI
SICI code
0951-4198(1997)11:11<1212:FMSOSF>2.0.ZU;2-K
Abstract
The mass spectrometric behaviour of a series of new derivatives of Fos carnet was studied with fast-atom bombardment and collision-induced di ssociation experiments in positive- and negative-ion modes. For the co mpounds esterified with a 2-(S-pivaloyl)thioethyl [tert-butyl)SATE] gr oup a rearrangement of the thioester linkage with expulsion of 60 u do minates the fragmentation pattern. (C) 1997 by John Wiley & Sons, Ltd.