One-year dog toxicity study of D-002 a mixture of aliphatic alcohols

D-002 is a mixture of high-molecular-weight aliphatic alcohols, obtained fr om bees wax (Apis mellifera), with mild anti-inflammatory properties and ef fective anti-ulcer activities demonstrated in experimental models. This stu dy investigated the oral toxicity of D-002 administered for 1 year to beagl e dogs. Twenty-four beagle dogs (12 males and 12 females) were distributed randomly in three experimental groups (four animals per group): a control a nd two treated groups received D-002 at 50 and 250 mg kg(-1) (7 days/week) by gastric gavage, Overall, D-002 was well tolerated throughout the study. No signs or symptoms of toxicity were observed, and no mortality occurred d uring the study, All groups showed similar weight gain and food consumption . No hematological, blood biochemical or histopathological disturbances att ributable to treatment were observed. This study shows no drug-related toxi city induced by long-term administration of up to 250 mg kg(-1) D-002 to be agle dogs. Copyright (C) 2001 John Wiley & Sons, Ltd.