Detoxification of lantana hepatotoxin, lantadene A, using Alcaligenes faecalis

Detoxification of lantadene A (LA), the hepatotoxin from Lantana camara var . aculeata, by the bacterial strain Alcaligenes faecalis has been investiga ted. Lantadene A induced hepatotoxicity concomitant with increases in plasm a bilirubin, blood plasma enzymes and histopathological lesions that typify lantana toxicity. The extract of fermentation broth in which LA was incuba ted with A. faecalis did not elicit any alterations in blood enzyme prolife or liver histopathology, which were comparable with the control group. It is concluded that A. faecalis detoxified LA and no noxious product was form ed on incubation of LA with A. faecalis, Copyright (C) 2001 John Wiley & So ns, Ltd.