Contribution to the penetration of radionuclides across the skin. Concentration dependence of strontium through the skin in vitro

Toxicological studies of radionuclide passage across the skin, which repres ents a crucial barrier of radiation, are important for ensuring the quality of the environment. Both Cs-137 and Sr-90 are most frequently involved in radionuclide contamination of the human body. In our study, we selected 90S r because this radionuclide is chemically very close to the bio-element cal cium. The permeation of 90Sr from donor solution across the intact skin of 5- or 9-day-old rats (5DR, 9DR) and across stripped and splitted skin of th e 5DR was studied, The experiments in vitro were carried out using vertical diffusion cells. Strontium chloride (SrCl2) was used as carrier in the don or solution in different concentrations. Liquid scintillation spectrometry was applied for radiation detection. The experiments showed that: the permeated fraction of Sr-90(2+) was indire ctly proportional to the carrier concentration in the donor solution; the s tratum corneum was found to be the principal penetration barrier of stronti um; and in the case of the 9DR the dominant route of strontium penetration was along the follicles, Copyright (C) 2001 John Wiley & Sons, Ltd.