ENANTIOSELECTIVE REDUCTION OF PROCHIRAL KETONES CATALYZED BY NEW MERCAPTO)METHYL-5,5-DIPHENYL-1,3,2-OXAZABOROLIDINE AND BIS-[(R,R)-5,5-DIPHENYL-1,3,2-OXAZABOROLIDINE METHYL]DISULFIDE FROM L-CYSTINE

Authors
LI XS XIE RG
Citation
Xs. Li et Rg. Xie, ENANTIOSELECTIVE REDUCTION OF PROCHIRAL KETONES CATALYZED BY NEW MERCAPTO)METHYL-5,5-DIPHENYL-1,3,2-OXAZABOROLIDINE AND BIS-[(R,R)-5,5-DIPHENYL-1,3,2-OXAZABOROLIDINE METHYL]DISULFIDE FROM L-CYSTINE, Tetrahedron : asymmetry, 8(14), 1997, pp. 2283-2285
Citations number
11
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Inorganic & Nuclear","Chemistry Physical
Journal title
Tetrahedron : asymmetry → ACNP
ISSN journal
09574166
Volume
8
Issue
14
Year of publication
1997
Pages
2283 - 2285
Database
ISI
SICI code
0957-4166(1997)8:14<2283:EROPKC>2.0.ZU;2-L
Abstract
Two new optically active beta-amino alcohols 1 and 2 were prepared fro m L-cystine. The in situ formed chiral oxazaborolidines have been used in the enantioselective catalytic homogeneous borane reduction of pro chiral ketones and diketones. The chiral secondary alcohols are obtain ed with moderate to good enantiomeric excess. (C) 1997 Elsevier Scienc e Ltd.