Inhibition of chitin synthetase from Saccharomyces cerevisiae by a new UDP-GlcNAc analogue

Authors
Behr, JB Gautier-Lefebvre, I Mvondo-Evina, C Guillerm, G Ryder, NS
Citation
Jb. Behr et al., Inhibition of chitin synthetase from Saccharomyces cerevisiae by a new UDP-GlcNAc analogue, J ENZ INHIB, 16(2), 2001, pp. 107-112
Citations number
29
Categorie Soggetti
Biochemistry & Biophysics
Journal title
JOURNAL OF ENZYME INHIBITION
ISSN journal
87555093 → ACNP
Volume
16
Issue
2
Year of publication
2001
Pages
107 - 112
Database
ISI
SICI code
8755-5093(2001)16:2<107:IOCSFS>2.0.ZU;2-W
Abstract
The synthesis and biological evaluation of a new UDP-GlcNAc competitor (I), designed to mimic the transition state of the sugar donor in the enzymatic reaction catalysed by chitin synthetase, is described. Compound (I) was fo und to competitively inhibit chitin synthetase from Saccharomyces cerevisia e with respect to UDP-G1cNAc, but displayed minimal antifungal activity.