Citation
La. Peterson et al., An improved synthesis of radiolabeled 4-(acetoxymethylnitrosamino)-1-(3-pyridyl)1-butanone, J LABEL C R, 44(6), 2001, pp. 445-450
Citations number
11
Categorie Soggetti
Chemistry & Analysis","Inorganic & Nuclear Chemistry
Journal title
JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS
ISSN journal
03624803
→ ACNP
Volume
44
Issue
6
Year of publication
2001
Pages
445 - 450
Database
ISI
SICI code
0362-4803(200105)44:6<445:AISOR4>2.0.ZU;2-E
Abstract
The syn thesis of high specific activity tritium-labeled 4-(acetoxymethylni
tro-samino)-1-(3-pyridyl)-1-butanone is reported. This compound was prepare
d by tritiation of 4-(acetoxymethylnitrosamino)-1-[3-(5-bromo)-pyridyl]-1-b
utanone (5-BrNNKOAc) in the presence of 10% Pd/C catalyst, yielding a produ
ct with a specific activity of 11.9 Ci/mmol. This pathway represents a majo
r improvement over previously published methods. Copyright (C) 2001 John Wi
ley & Sons, Ltd.