Synthesis of ring-C-14-labelled 4(3 '-,6 '-dimethyl-3 '-heptyl)-phenol

Authors
Lalah, JO Lenoir, D Henkelmann, B Hertkorn, N Gunther, K Schramm, KW Kettrup, A
Citation
Jo. Lalah et al., Synthesis of ring-C-14-labelled 4(3 '-,6 '-dimethyl-3 '-heptyl)-phenol, J LABEL C R, 44(6), 2001, pp. 459-463
Citations number
10
Categorie Soggetti
Chemistry & Analysis","Inorganic & Nuclear Chemistry
Journal title
JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS
ISSN journal
03624803 → ACNP
Volume
44
Issue
6
Year of publication
2001
Pages
459 - 463
Database
ISI
SICI code
0362-4803(200105)44:6<459:SOR4''>2.0.ZU;2-Y
Abstract
Ring-C-14-labelled 4(3'-, 6'-, dimethyl-3'-,heptyl)-phenol (NP), an isomer of paranonyl phenol was synthesized for use in aquatic toxicity and metabol ism studies. A very efficient method involving alkylation of ring-C-14-labe led anisole and tertiary alkyl bromide (3-bromo-3,6-dimethyl heptane) with AlCl3 followed by cleavage of the resultant ether with BBr3 was used giving a 24% yield ring labelled C-14-NP (specific activity: 16.205 MBq/mg and pu rity > 95% by HPLC) after TLC separation. Copyright (C) 2001 John Wiley & S ons, Ltd.