Estrogen regulated proteases and antiproteases in ovarian and breast cancer cells

Authors
Rochefort, H Chalbos, D Cunat, S Lucas, A Platet, N Garcia, M
Citation
H. Rochefort et al., Estrogen regulated proteases and antiproteases in ovarian and breast cancer cells, J STEROID B, 76(1-5), 2001, pp. 119-124
Citations number
49
Categorie Soggetti
Biochemistry & Biophysics
Journal title
JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY
ISSN journal
09600760 → ACNP
Volume
76
Issue
1-5
Year of publication
2001
Pages
119 - 124
Database
ISI
SICI code
0960-0760(200101/03)76:1-5<119:ERPAAI>2.0.ZU;2-#
Abstract
Cathepsin D (cath-D), an estrogen-regulated protease appears mostly to incr ease the number of tumor cells rather than their invasion or motility throu gh the extracellular matrix. Estradiol is mitogenic but in vitro it also in hibits invasion and motility. In this review, we discuss the mechanism of t his inhibition and the hormonal regulation of other proteases and protease inhibitors possibly involved in the control of tumor cell invasion by estro gens. (C) 2001 Elsevier Science Ltd. All rights reserved.