Kinetics and mechanism of oxidation of hexoses by bromamine-T in alkaline medium

The kinetics and mechanism of oxidation of D-glucose and D-mannose with bro mamine-T in alkaline medium have been studied and the rate = k[BAT] [sugar] [OH-](2), is observed. The rate of the reaction is influenced by a change i n ionic strength of the medium and the dielectric effect is found to be pos itive. The latter enables the computation of d(AB), the size of the activat ed complex. Proton inventory studies are made for the reactions in H2O-D2O mixtures. Activation parameters are calculated from the Arrhenius plots. Th e product analyses indicates that the sugars are oxidized to a mixture of a ldonic acids, consisting of arabinonic, ribonic, erythronic and glyceric ac ids. A mechanism consistent with the observed kinetics has been proposed.