Human immunodeficiency virus (HIV) and syphilis are relationship-based dise
ases that ave typically transmitted by the cooperative activities (sex or d
rug injection) of two persons. A sample of 215 drug users and 52 sociodemog
raphically matched nonusers was collected to examine the behaviors and rela
tionships related to HIV and syphilis transmission. Results showed that, al
though drug users had more risk opportunities (more sex partners and, of co
urse, more injection partners) than nonusers, actual sex risk behaviors (ne
ver using condoms) did not differ appreciably among drug users and nonusers
or with opposite-sex partners and same-sex partners. The similarity of sex
ual risk was supported by the similar levels of syphilis between drug users
and nonusers. The unique risk to drug users was drug injection, although d
rug users were found to engage in fewer risky injection behaviors (sharing
of drug injection equipment) than the risky sexual behaviors in which all p
articipants engaged. Although drug users interacted as frequently with part
ners as nonusers, nonuser relationships were longer lasting and emotionally
closer.