West Nile virus is transmitted by urban-dwelling mosquitoes to birds and ot
her animals, with occasional "spillover" to humans. While the means by whic
h West Nile virus was introduced into the Americas in 1999 remain unknown,
the climatic conditions that amplify diseases that cycle among urban mosqui
toes, birds, and humans are warm winters and spring droughts. This informat
ion can be useful in generating early warning systems and mobilizing timely
and the most environmentally friendly public health interventions. The ext
reme weather conditions accompanying long-term climate change may also be c
ontributing to the spread of West Nile virus in the United States and Europ
e.