Nj. Reynolds et al., Narrow-band ultraviolet B and broad-band ultraviolet A phototherapy in adult atonic eczema: a randomised controlled trial, LANCET, 357(9273), 2001, pp. 2012-2016
Citations number
33
Categorie Soggetti
General & Internal Medicine","Medical Research General Topics
Background Narrow-band ultraviolet B (UVB) is an effective treatment for ps
oriasis, and open studies suggest that this phototherapy might improve atop
ic eczema. We did a randomised controlled trial to compare narrow-band UVB,
UVA, and visible light phototherapy as second-line, adjunctive treatments
in adult patients with moderate to severe atopic eczema.
Methods Phototherapy was administered twice a week for 12 weeks. 26 patient
s were randomly assigned narrow-band UVB, 24 were assigned UVA, and 23 visi
ble fluorescent light. The primary endpoints were change in total disease a
ctivity (sum of scores at six body sites) and change in extent of disease a
fter 24 treatments compared with baseline. Data were analysed by the method
of summary measures.
Findings 13 patients withdrew or were excluded from analysis. Mean reductio
ns in total disease activity over 24 treatments in patients who received na
rrow-band UVB and UVA, respectively, were 9.4 points (95% CI 3.6 to 15.2)an
d 4.4 points ( - 1.0 to 9.8) more than in patients who received visible lig
ht. Mean reductions in extent of disease after 24 treatments with narrow-ba
nd UVB and UVA were 6.7% (1.5 to 11.9) and -1.0% (-5.3 to 3.3)compared with
visible light. A small proportion of patients developed erythema after pho
totherapy or had a flare in their eczema sufficient to withdraw from treatm
ent.
Interpretation Narrow-band UVB is an effective adjunctive treatment for mod
erate to severe atopic eczema, and the treatment is well tolerated by most
patients.