ANALYSIS OF RADIATION DOSE-RESPONSE CURVE OBTAINED WITH CYTOKINESIS BLOCK MICRONUCLEUS ASSAY

The frequency of micronuclei and acentrics obtained with different dos es of Co-60 gamma radiation was examined. When compared to acentric fr equency the micronuclei frequency was found to be higher at about 115% for doses below 1 Gy. However, it dropped to about 65% as the dose wa s increased to 4 Gy. This paper discusses the causes for the reduced f requency of micronuclei at higher doses by taking into account the pos sibility of their being masked from view by the daughter nuclei in the binucleated cell. (C) 1997 Elsevier Science Inc.