IN-VITRO AND IN-VIVO PROPERTIES OF MURINE MONOCLONAL-ANTIBODY FOR A NOVEL IMMATURE THYMOCYTE-DIFFERENTIATED ANTIGEN, JL1

Authors
CHUNG JK SO Y HONG MK CHOI SR JEONG JM LEE DS LEE MC KOH CS CHOI EY PARK SH
Citation
Jk. Chung et al., IN-VITRO AND IN-VIVO PROPERTIES OF MURINE MONOCLONAL-ANTIBODY FOR A NOVEL IMMATURE THYMOCYTE-DIFFERENTIATED ANTIGEN, JL1, Nuclear medicine and biology, 24(5), 1997, pp. 433-437
Citations number
18
Categorie Soggetti
Radiology,Nuclear Medicine & Medical Imaging
Journal title
Nuclear medicine and biology
ISSN journal
09698051 → ACNP
Volume
24
Issue
5
Year of publication
1997
Pages
433 - 437
Database
ISI
SICI code
0969-8051(1997)24:5<433:IAIPOM>2.0.ZU;2-F
Abstract
JL1 is a novel thymocyte-differentiated antigen strictly confined to s tage II immature cortical thymocytes. It is expressed in several types of leukemias and lymphomas. Murine anti-JL1 monoclonal antibody label ed with I-131 and Tc-99m showed 60-70% of immunoreactivity and 1.4-1.9 x 10(9) L/mol of affinity constant. The incubation of the radiolabele d antibody with Molt-4 cells showed no evidence of modulation or shedd ing. Localization indices increased from day 3 to day 5 in SCID mice b earing Molt-4 cells. (C) 1997 Elsevier Science Inc.