Da. Butterfield et J. Kanski, Brain protein oxidation in age-related neurodegenerative disorders that are associated with aggregated proteins, MECH AGE D, 122(9), 2001, pp. 945-962
Protein oxidation, one of a number of brain biomarkers of oxidative stress,
is increased in several age-related neurodegenerative disorders or animal
models thereof including Alzheimer's disease, Huntington's disease, prion d
isorders, such as Creutzfeld-Jakob disease, and alpha -synuclein disorders,
such as Parkinson's disease and frontotemporal dementia. Each of these neu
rodegenerative disorders is associated with aggregated proteins in brain. H
owever, the relationship among protein oxidation. protein aggregation. and
neurodegeneration remain unclear. The current rapid progress in elucidation
of mechanisms of protein oxidation in neuronal loss should provide further
insight into the importance of Free radical oxidative stress in these neur
odegenerative disorders. (C) 2001 Elsevier Science Ieeland Ltd. All rights
reserved.