Several laboratories in studies of various brain areas have reported a depe
ndence of long-term potentiation (LTP) and long-term depression (LTD) on th
e relative timing of presynaptic and postsynaptic activities. The observati
on that LTP occurs when presynaptic activity precedes postsynaptic activity
is consistent with Hebbian ideas regarding prediction. However, the comput
ational role of LTD under the opposite condition (postsynaptic precedes pre
synaptic) does not find an easy explanation. Here, we propose that this for
m of LTD stabilizes learning of temporal associations. This conjecture is d
emonstrated in two tasks, and compared with another possible stabilizing me
chanism, weight decay. (C) 2001 Elsevier Science B.V. All rights reserved.