Control of network output by synaptic depression

In a network of an excitatory and an inhibitory neuron, depression in the i nhibitory synapse can produce two distinct oscillatory regimes. In one regi me, the network has a short period cell-dominated solution; in the other re gime, the solution has much longer period and is synapse-dominated. These r egimes overlap to produce an interval of bistability. Neuromodulatory input that targets one of multiple parameters in the network can switch the netw ork control between the intrinsic properties of cells and the dynamics of t he synapses. (C) 2001 Elsevier Science B.V. All rights reserved.