Expression of the non-compact myelin protein 2 ',3 '-cyclic nucleotide 3 '-phosphodiesterase (CNPase) in olfactory bulb ensheathing glia from explantcultures

The non-compact myelin protein 2 ' ,3 ' -cyclic nucleotide 3 ' -phosphodies terase (CNPase) may have a unique role in signaling pathways mediated by li pid-protein domains (Kiln and Pfeiffer. 1999). Wt have tested for CNPase in olfactory bulb ensheathing glia (OBEG) in explant cultures. Migrating bipo lar and multipolar cells with OBEG typical morphologies were immunoreactive For both vimentin- and S100-like: proteins. Although apparently devoid of myelin basic protein (MBP)-like immunoreactivity. these cells displayed wea k but unambiguous CNPase-like immunoreactivity. Our results suggest a furth er resemblance to myelinating Schwann cells. (C) 2001 Elsevier Science Irel and Ltd and the Japan Neuroscience Society. All rights reserved.