LONGITUDINAL ANALYSIS OF OLFACTORY DEFICITS IN HIV-INFECTION

The presence and degree of odor identification deficits in 55 HIV-infe cted (30 asymptomatic, 25 symptomatic) and 29 HIV-negative at-risk con trol volunteers were examined longitudinally using the University of P ennsylvania Smell Identification Test (UPSIT). Factors other than HIV infection that could account for olfactory loss (i.e., sinusitis or up per respiratory infection) were also considered by obtaining MRI scans of the nasal passages and information from an olfaction questionnaire . No differences were found among groups at the first administration o f the UPSIT, with significant differences among groups emerging at the 1-year and 2-year follow-ups. The symptomatic group showed a signific ant decline in odor identification scores across time, while means for the asymptomatic and control groups remained stable. The presence of sinusitis or an upper respiratory infection appeared to have no effect on odor identification. The implications for these findings in relati onship to cognitive decline in neurodegenerative diseases are discusse d. (C) 1997 National Academy of Neuropsychology. Published by Elsevier Science Ltd.