The relative-space-time-transformation (RSTT) paradigm and tire interpretat
ion of the burst-structure (IBS) paradigm are applied to probe the origin o
f the time variability of GRBs. Again GRB 991216 is used as a prototypical
case, thanks to the precise data from the CGRO, RXTE: and Chandra satellite
s. It is found that with the exception of the relatively. inconspicuous but
scientifically very important signal originating from the initial "proper
gamma ray burst" (P-GRB), all the other spikes and time variabilities call
be explained by the interaction of the accelerated-baryonic-matter pulse wi
th inhomogeneities in the interstellar matter. This call be demonstrated by
using the RSTT paradigm as well as the IBS paradigm, to trace a typical sp
ike observed in arrival time back to the corresponding one ill the laborato
ry time. Using these paradigms, the identification of tire physical nature
of the time variablity of the GRBs carl be made most convincingly. It is ma
de explicit the dependence of a) the intensities of the afterglow, b) the s
pikes amplitude and c) the actual time structure on the Lorentz gamma facto
r of the accelerated-baryonic-matter pulse. In principle it is possible to
read off from the spike structure the detailed density contrast of the inte
rstellar medium in the host galaxy, even at very high redshift.