Oro-dental and craniofacial anomalies in LEOPARD syndrome

'LEOPARD syndrome' is a syndrome affecting many systems or organs, The main anomalies are summarized in the acronym LEOPARD in which each letter corre sponds to the damage of a given organ, In the presented case, there are ore -dental and craniofacial anomalies, The relationship between the LEOPARD sy ndrome and the given anomalies and the possibilities of the management and the follow-up of the diseased are studied, The clinical case presented is a 4-year-old boy with LEOPARD syndrome showing retardation of dental develop ment, delayed development and possible agenesis of permanent teeth, and cra niofacial anomalies (osseous hypo-development). The bibliographical study s hows that LEOPARD syndrome is due to damage of the neural crest cells. Thus , the dental and craniofacial anomalies arise, since neural crest cells par ticipate in the formation of the teeth and some cranofacial bones, Therefor e, dental and craniofacial anomalies might be expected in some cases of the disease. The therapeutic management of the lesions, and the follow-up of t he patient would be done by a multidisciplinary team.