Rotavirus infection as cause of tacrolimus elevation in solid-organ-transplanted children

Rotavirus (RV) is the most common cause of diarrheal illness in children. W e report three solid-organ-transplanted patients ill whom RV infection caus ed increased trough levels of the immunosuppressive macrolide tacrolimus (T AC) by mechanisms that are still under investigation. The virus was detecte d for longer in the feces of these patients than in infants not receiving i mmunosuppressive therapy. In association with short-term monitoring of bloo d trough levels of TAC. the dosage should be reduced early if symptoms of a n acute: gastroenteritis are present.