Elevated tacrolimus trough levels in association with mycophenolate mofetil-induced diarrhea: A case report

Authors
Fruhwirth, M Fischer, H Simma, B Ellemunter, H
Citation
M. Fruhwirth et al., Elevated tacrolimus trough levels in association with mycophenolate mofetil-induced diarrhea: A case report, PEDIAT TRAN, 5(2), 2001, pp. 132-134
Citations number
14
Categorie Soggetti
Pediatrics
Journal title
PEDIATRIC TRANSPLANTATION
ISSN journal
13973142 → ACNP
Volume
5
Issue
2
Year of publication
2001
Pages
132 - 134
Database
ISI
SICI code
1397-3142(200104)5:2<132:ETTLIA>2.0.ZU;2-#
Abstract
The combination of tacrolimus (TAC) and mycophenolate mofetil (MMF) is freq uently used for immunosuppression after organ transplantation (Tx)l but the pharmacokinetics and intel actions between the two drugs are poorly elucid ated. We describe here the increase of TAC trough levels during MMF-induced diarrhea in a 8-yr-old boy after kidney Tx. Early dose reduction of TAG, t ogether with short-term monitoring of TAC trough levels in the presence of diarrhea, is recommended.