Analytical data and physicochemical properties of 1-(4-chlorphenyl)-4-morpholino-imidazolin-2-one, AWD 131-138

The structure of the anticonvulsant 1-(4-chlorophenyl)-4-(4-morpholinyl)-2, 5-dihydro-1H-imidazolin-2-one (Code: AWD 131-138, CAS-No.: 188116-07-6) was proved by IR, UV, (HNMR)-H-1, (CNMR)-C-13 and mass spectra. AWD 131-138 is practically insoluble in a neutral aqueous medium at 20 degreesC (S simila r to 0.08 g/l). The solubility of the substance in 0.1 N HCl is about 2.7 g /l. In DMF, AWD 131-138 is sparingly soluble (S similar to 28.5 g/l). The p K(a)-value is about 2.5. The partition coefficients P = C-Octanol/C-water a t 37 degreesC range from 0.7 at pH similar to 1 to about 20 at pH greater t han or equal to 6.