A model of cardiac cellular electromechanics

Authors
Nickerson, DP Smith, NP Hunter, PJ
Citation
Dp. Nickerson et al., A model of cardiac cellular electromechanics, PHI T ROY A, 359(1783), 2001, pp. 1159-1172
Citations number
40
Categorie Soggetti
Multidisciplinary
Journal title
PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY OF LONDON SERIES A-MATHEMATICAL PHYSICAL AND ENGINEERING SCIENCES
ISSN journal
1364503X → ACNP
Volume
359
Issue
1783
Year of publication
2001
Pages
1159 - 1172
Database
ISI
SICI code
1364-503X(20010615)359:1783<1159:AMOCCE>2.0.ZU;2-W
Abstract
A coupled electromechanics model of a single cardiac cell is used to interp ret a wide variety of experimental tests and is compared to a limited exten t (since no other cardiac model dealing with the full range of mechanical t ests is available) with other models of myofilament mechanics. We consider the passive elasticity of the cell, troponin-C-calcium binding kinetics, th in filament kinetics, the length dependence of steady-state tension, cross- bridge kinetics, and the coupling of mechanics to cell electrophysiology (t he Noble 98 model) via the calcium transient.