Despite its critical role in restoring cardiac rhythm and thus, in saving h
uman life, cardiac defibrillation remains poorly understood. For a defibril
lation shock to be successful, the shock must extinguish existing activatio
n fronts throughout the myocardium without initiating new re-entrant activa
tions. The goal of this paper is to examine the current theories for defibr
illation and re-entry induction, the new breakthroughs in the field, and th
e emerging new hypotheses.