ARYLIMINO-1,2,4-THIADIAZOLIDINONES - A NEW FAMILY OF POTASSIUM CHANNEL OPENERS

A series of arylimino-1,2,4-thiadiazolidines were prepared using an ef ficient synthesis starting from thiadiazolopyridinium chlorides. All t he compounds showed smooth muscular relaxant properties in rat portal veins. The different behaviour under highly depolarized conditions and the reduction of the biological effect by glyburide suggests that the arylimino-1,2,4-thiadiazolidin-3-ones may act, at least in part, via K+-induced hyperpolarization of vascular smooth cells. (C) 1997 Elsevi er Science Ltd.