We model and analyze a short section of a DNA chain with a defect, with the
aim of understanding how the frequency, amplitude, and localization of bre
athing events depend on the strength of the bonds between base pairs, both
along the chain and between the chains. Our results show that the presence
of a defect in the chain permits the existence of a localized breather mode
. The models we analyze are linear and hence solvable, with solvability ext
ending to the statistical mechanics formulation of the problem. Parameter v
alues for the interaction energy of a base with its nearest neighbors are o
btained from AMBER. The results indicate good agreement with both the ampli
tude and the number of base pairs affected by defect-induced breathing moti
on.