A rapid procedure for initial drug evaluation

The overall aim of this work is to develop computer simulations to aid in t he selection of proposed medicines and identify those most likely to succee d. One important feature is a systems approach to simulate both the target area with which the drug is designed to interact as well as the surrounding areas where feedback mechanisms may alter the expected effect. The simulat ion must be rapid if it is to be used to evaluate large numbers of potentia l drugs. Thus the procedure simplifies many of the known complex phenomena to provide a general framework and feedback mechanisms. An example of the u se of the simulation to study a drug used to treat hypertension is given. A possible use of the technique is shown using the example of the effect of varying the drug dosage on the contraction of the arteriole muscle.