Syntheses and antitumor activities of polymers containing 2-acrylamido-2-methyl-1-propanesulfonic acid or 5-fluorouracil

The polymers containing 2-acrylamido-2-methy1-1-propanesulfonic acid (AMPA) were prepared by radical polymerizations. The polymers were identified by FT-IR, H-1-, and C-13-NMR spectroscopies. The contents of AMPA unit in poly (AMPA-co-MAH), terpoly(AMPA-MAH-FUR), and poly(AMPA-co-EETFU) were 67, 73 a nd 49 mol %, respectively. The number average molecular weights of the poly mers determined by GPC were in range from 5,600 to 9,200. The IC50 values o f the synthesized polymers against cancer cell lines were in the range of 0 .02 to 127. The in vivo antitumor activities of polymers against Balb/C mic e bearing the sarcoma 180 tumor cells were greater than those of 5-FU.